0001104659-21-147673 4 1 20211206 20211208 20211208 Maccecchini Maria-Luisa 0001315018 4 34 001-39202 211479364 1223 FOXGLOVE LANE WEST CHESTER PA 19380 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm2134914-1_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2021-12-06 0 0001477845 Annovis Bio, Inc. ANVS 0001315018 Maccecchini Maria-Luisa C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 1 1 0 President and CEO Stock Option (right to buy) 20.97 2021-12-06 4 A 0 112995 0 A 2021-12-06 2031-12-06 Common Stock 112995 112995 D Stock Option (right to buy) 20.97 2021-12-06 4 A 0 145305 0 A 2031-12-06 Common Stock 145305 145305 D The stock option is 100% vested. The stock option shall vest in two installments: (i) the first installment of 72,653 shares on March 31, 2022 and (ii) a second and final installment of 72,652 shares on March 31, 2023, provided that the reporting person continues to be employed by the issuer on the applicable vesting date. /s/ Jeffrey McGroarty, Attorney-in-Fact for Maria L. Maccecchini 2021-12-08