0001104659-21-090745 4 1 20210707 20210709 20210709 McGroarty Jeffrey Brian 0001563273 4 34 001-39202 211083873 360 HILLTOP RD PAOLI PA 19301 McGroarty Jeffrey B 20121129 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm2121908-5_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2021-07-07 0 0001477845 Annovis Bio, Inc. ANVS 0001563273 McGroarty Jeffrey Brian C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 0 1 0 0 Chief Financial Officer Stock Option (right to buy) 102.85 2021-07-07 4 A 0 14000 0 A 2031-07-07 Common Stock 14000 14000 D The stock option shall vest in eight substantially equal quarterly installments beginning October 7, 2021, provided that the reporting person continues to be employed by the issuer on the applicable vesting date. /s/ Jeffrey McGroarty 2021-07-09