0001104659-21-090743 4 1 20210707 20210709 20210709 Maccecchini Maria-Luisa 0001315018 4 34 001-39202 211083866 1223 FOXGLOVE LANE WEST CHESTER PA 19380 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm2121908-3_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2021-07-07 0 0001477845 Annovis Bio, Inc. ANVS 0001315018 Maccecchini Maria-Luisa C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 1 1 0 President and CEO Stock Option (right to buy) 102.85 2021-07-07 4 A 0 41700 0 A 2031-07-07 Common Stock 41700 41700 D The stock option shall vest in eight substantially equal quarterly installments beginning October 7, 2021, provided that the reporting person continues to be employed by the issuer on the applicable vesting date. /s/ Jeffrey McGroarty, Attorney-in-Fact for Maria L. Maccecchini 2021-07-09