0001104659-23-005476 4 1 20230118 20230120 20230120 Hoffman Michael B 0001290208 4 34 001-39202 23542064 (203) 413-2200 1 GREENWICH OFFICE PARK GREENWICH CT 06831 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm234043-2_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2023-01-18 0 0001477845 Annovis Bio, Inc. ANVS 0001290208 Hoffman Michael B C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 0 1 0 Stock Option (right to buy) 13.17 2023-01-18 4 A 0 6820 0 A 2033-01-18 Common Stock 6820 6820 D The stock option shall vest in eight consecutive equal quarterly installments each on the 18th day of April, July, October and January of each year, commencing April 18, 2023, and continuing through January 18, 2025. /s/ Henry Hagopian III, Attorney-in-Fact for Michael Hoffman 2023-01-20