0001415889-21-004862 4 1 20211011 20211013 20211013 Maccecchini Maria-Luisa 0001315018 4 34 001-39202 211321254 1223 FOXGLOVE LANE WEST CHESTER PA 19380 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 form4-10132021_011036.xml X0306 4 2021-10-11 0001477845 Annovis Bio, Inc. ANVS 0001315018 Maccecchini Maria-Luisa C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 true true true false PRESIDENT AND CEO Common Stock 2021-10-11 4 P 0 18000 27.61 A 976775 D The price represents the weighted average purchase price for multiple transactions reported on this line. The prices of the transactions ranged from $27.58 to $27.64, inclusive. Upon request of the SEC staff or the issuer, the reporting person will provide full information regarding the number of shares purchased at each separate price. /s/ Jeffrey McGroarty, Attorney-in-Fact for Maria L. Maccecchini 2021-10-12