0001104659-23-044203 4 1 20230407 20230411 20230411 McCarthy Reid 0001857733 4 34 001-39202 23814489 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm2312464-2_4seq1.xml OWNERSHIP DOCUMENT X0407 4 2023-04-07 0 0001477845 Annovis Bio, Inc. ANVS 0001857733 McCarthy Reid C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 0 0 0 0 Common Stock 2023-04-07 4 A 0 476 12.61 A 7305 D /s/ Henry Hagopian, III, Attorney-in-Fact for Reid S. McCarthy 2023-04-11