0001104659-22-001640 4 1 20220103 20220105 20220105 Maccecchini Maria-Luisa 0001315018 4 34 001-39202 22513180 1223 FOXGLOVE LANE WEST CHESTER PA 19380 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm221949-3_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2022-01-03 0 0001477845 Annovis Bio, Inc. ANVS 0001315018 Maccecchini Maria-Luisa C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 1 1 0 President and CEO Stock Option (right to buy) 19.78 2022-01-03 4 A 0 83400 0 A 2032-01-03 Common Stock 83400 83400 D Stock Option (right to buy) 19.78 2022-01-03 4 A 0 19894 0 A 2032-01-03 Common Stock 19894 19894 D The stock option shall vest in eight consecutive quarterly installments of 10,425 shares each on the 3rd day of April, July, October and January of each year, commencing April 3, 2022, and continuing through January 3, 2024. The stock option shall vest and become exercisable in two equal installments of 9,947 shares on March 31, 2022 and March 31, 2023. /s/ Jeffrey McGroarty, Attorney-in-Fact for Maria L. Maccecchini 2022-01-05