0001104659-22-005059 4 1 20220114 20220118 20220118 Maccecchini Maria-Luisa 0001315018 4 34 001-39202 22536605 1223 FOXGLOVE LANE WEST CHESTER PA 19380 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm221949-7_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2022-01-14 0 0001477845 Annovis Bio, Inc. ANVS 0001315018 Maccecchini Maria-Luisa C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 1 1 0 President and CEO Common Stock 2022-01-14 4 M 0 32959 0.14 A 987734 D Stock Option (right to buy) 0.14 2022-01-14 4 M 0 32959 0 D 2027-04-01 Common Stock 32959 52755 D All of the shares underlying the option are fully vested and exercisable. /s/ Jeffrey McGroarty, Attorney-in-Fact for Maria L. Maccecchini 2022-01-18