0001104659-22-001638 4 1 20220103 20220105 20220105 Hoffman Michael B 0001290208 4 34 001-39202 22513173 (203) 413-2200 1 GREENWICH OFFICE PARK GREENWICH CT 06831 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm221949-2_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2022-01-03 0 0001477845 Annovis Bio, Inc. ANVS 0001290208 Hoffman Michael B C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 0 1 0 Common Stock 2022-01-04 4 M 0 30000 4.39 A 1415889 D Common Stock 2022-01-04 4 F 0 6658 19.78 D 1409231 D Common Stock 2022-01-04 4 M 0 7142 0.25 A 1416373 D Common Stock 2022-01-04 4 F 0 90 19.78 D 1416283 D Stock Option (right to buy) 19.78 2022-01-03 4 A 0 9000 0 A 2032-01-03 Common Stock 9000 9000 D Stock Option (right to buy) 4.39 2022-01-04 4 M 0 30000 0 D 2020-07-01 2030-07-01 Common Stock 30000 0 D Stock Option (right to buy) 0.25 2022-01-04 4 M 0 7142 0 D 2018-04-06 2028-04-06 Common Stock 7142 0 D Reflects 6,658 shares withheld by issuer at the market price of $19.78 per share less an exercise price of $4.39 per share to fund the cashless exercise of 30,000 options. Reflects 90 shares withheld by issuer at the market price of $19.78 per share less an exercise price of $0.25 per share to fund the cashless exercise of 7,142 options. The stock option shall vest in eight consecutive quarterly installments of 1,125 shares each on the 3rd day of April, July, October and January of each year, commencing April 3, 2022, and continuing through January 3, 2024. /s/ Jeffrey McGroarty, Attorney-in-Fact for Michael Hoffman 2022-01-05