0001104659-22-001637 4 1 20220103 20220105 20220105 Bruck Claudine 0001733680 4 34 001-39202 22513167 4995 BRADENTON AVE, SUITE 240 DUBLIN OH 43017-3552 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm221949-1_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2022-01-03 0 0001477845 Annovis Bio, Inc. ANVS 0001733680 Bruck Claudine C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 0 0 0 Stock Option (right to buy) 19.78 2022-01-03 4 A 0 8000 0 A 2032-01-03 Common Stock 8000 8000 D The stock option shall vest in eight consecutive quarterly installments of 1,000 shares each on the 3rd day of April, July, October and January of each year, commencing April 3, 2022, and continuing through January 3, 2024. /s/ Jeffrey McGroarty, Attorney-in-Fact for Claudine Bruck 2022-01-05