0001104659-23-005475 4 1 20230118 20230120 20230120 Bruck Claudine 0001733680 4 34 001-39202 23542058 4995 BRADENTON AVE, SUITE 240 DUBLIN OH 43017-3552 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm234043-1_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2023-01-18 0 0001477845 Annovis Bio, Inc. ANVS 0001733680 Bruck Claudine C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 0 0 0 Stock Option (right to buy) 13.17 2023-01-18 4 A 0 5967 0 A 2033-01-18 Common Stock 5967 5967 D The stock option shall vest in eight consecutive equal quarterly installments each on the 18th day of April, July, October and January of each year, commencing April 18, 2023, and continuing through January 18, 2025. /s/ Henry Hagopian, III, Attorney-in-Fact for Claudine Bruck 2023-01-20