0001104659-23-005480 4 1 20230118 20230120 20230120 Hagopian Henry III 0001821822 4 34 001-39202 23542078 C/O ORGANOGENESIS INC., 85 DAN ROAD CANTON MA 02021 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm234043-5_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2023-01-18 0 0001477845 Annovis Bio, Inc. ANVS 0001821822 Hagopian Henry III C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 0 1 0 0 Chief Financial Officer Stock Option (right to buy) 13.17 2023-01-18 4 A 0 7672 0 A 2033-01-18 Common Stock 7672 7672 D The stock option shall vest in eight consecutive quarterly installments of 1,918 shares each on the 18th day of April, July, October and January of each year, commencing April 18, 2023, and continuing through January 18, 2025. /s/ Henry Hagopian III 2023-01-20