0001104659-23-005481 4 1 20230118 20230120 20230120 Maccecchini Maria-Luisa 0001315018 4 34 001-39202 23542081 1223 FOXGLOVE LANE WEST CHESTER PA 19380 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm234043-6_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2023-01-18 0 0001477845 Annovis Bio, Inc. ANVS 0001315018 Maccecchini Maria-Luisa C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 1 1 0 President and CEO Stock Option (right to buy) 13.17 2023-01-18 4 A 0 21312 0 A 2033-01-18 Common Stock 21312 21312 D The stock option shall vest in eight consecutive quarterly installments of 2,664 shares each on the 18th day of April, July, October and January of each year, commencing April 18, 2023, and continuing through January 18, 2025. /s/ Henry Hagopian III, Attorney-in-Fact for Maria L. Maccecchini 2023-01-20