0001104659-21-090741 4 1 20210707 20210709 20210709 Bruck Claudine 0001733680 4 34 001-39202 211083863 4995 BRADENTON AVE, SUITE 240 DUBLIN OH 43017-3552 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm2121908-1_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2021-07-07 0 0001477845 Annovis Bio, Inc. ANVS 0001733680 Bruck Claudine C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 0 0 0 Stock Option (right to buy) 102.85 2021-07-07 4 A 0 4000 0 A 2031-07-07 Common Stock 4000 4000 D The stock option shall vest in eight substantially equal quarterly installments beginning October 7, 2021, provided that the reporting person continues to serve as a director of the issuer on the applicable vesting date. /s/ Jeffrey McGroarty, Attorney-in-Fact for Claudine Bruck 2021-07-09