0001104659-20-046066 4 1 20200409 20200413 20200413 Maccecchini Maria-Luisa 0001315018 4 34 001-39202 20789747 1223 FOXGLOVE LANE WEST CHESTER PA 19380 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 a4.xml 4 X0306 4 2020-04-09 0 0001477845 Annovis Bio, Inc. ANVS 0001315018 Maccecchini Maria-Luisa C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 1 1 0 President and CEO Stock Option (right to buy) 3.13 2020-04-09 4 A 0 300000 0 A 2020-04-09 2030-04-09 Common Stock 300000 300000 D /s/ Maria Maccecchini 2020-04-13