{\rtf1\ansi\ansicpg1252\uc1\deff0\deflang1033 {\colortbl\red0\green0\blue0;\red1\green1\blue1;}{\fonttbl{\f2\fswiss Arial;}{\f1\fmodern Courier New;}{\f3\fdecor Symbol;}{\f0\froman Times New Roman;}{\f4\fnil Wingdings;}} {\info{\subject EDGAR Online Pro}{\version3}{\*\company EDGAR Online, Inc.}{\author EDGAR Online HTML to RTF Converter. Version 3.0}{\*\category \0001104659-20-007806.html.ecq}{\doccomm Source: EDGAR Online, Inc. \'a9 Copyright 2020. All rights reserved.}{\title Annovis Bio, Inc. (Form: S-1MEF, Received: 01/29/2020 06:07:37)}} \paperh15840\paperw12240\margl360\margr360\margt360\margb360\headery0\footery360\sprstsp\sprsbsp\sprsspbf\sprslnsp\widowctrl\viewscale100 {\*\bkmkstart eolPage1}{\*\bkmkend eolPage1}{\*\bkmkstart FIS_TOP_OF_DOCUMENT}{\*\bkmkend FIS_TOP_OF_DOCUMENT}{\*\bkmkstart A19_9635_14S1MEF_HTM}{\*\bkmkend A19_9635_14S1MEF_HTM}{\*\bkmkstart FIS_FORM}{\*\bkmkend FIS_FORM}\pard \qc {\fs20 {\fs6 \u160?}}\par \pard \qc \sb1 {\fs20 {\b {\b As filed with the Securities and Exchange Commission on January\u160?29, 2020}}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par \pard \qr \sb1 {\fs20 {\b {\b Registration No.\u160?333-\u160?\u160?\u160?\u160?\u160?}}}\par \pard \sb80 {\fs20 {\fs2 \u160?}}\par \pard \sb40 {\fs20 {\fs6 \u160?}}\par \pard \qc \sb1 {\fs20 {\b {\fs36\b UNITED STATES}}}\par \pard \qc \sb1 {\fs20 {\b {\fs36\b SECURITIES AND EXCHANGE COMMISSION}}}\par \pard \qc \sb1 {\fs20 {\b {\b Washington, D.C. 20549}}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}{\*\bkmkstart FIS_UNIDENTIFIED_TABLE}{\*\bkmkend FIS_UNIDENTIFIED_TABLE}\par \pard \qc \sb1 {\fs20 {\b {\fs36\b FORM\u160?S-1}}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par \pard \qc \sb1 {\fs20 {\b {\fs24\b REGISTRATION STATEMENT}}}\par \pard \qc \sb1 {\fs20 {\b {\fs24\b UNDER}}}\par \pard \qc \sb1 {\fs20 {\b {\fs24\b THE SECURITIES ACT OF\u160?1933}}}\par \pard \qc \sb1 {\fs20 {\b {\fs36\b ANNOVIS BIO,\u160?INC.}}}\par \pard \qc \sb1 {\fs20 {(Exact name of registrant as specified in its charter)}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par {\pard\sl-1\par} {\trowd\trleft0\cellx3675 \clvertalb\cellx3924 \cellx7598 \clvertalb\cellx7846 \cellx11520 \pard \intbl\qc \ri16 {\fs20 {\b {\b Delaware}}\line (State or other jurisdiction of\line incorporation or organization)}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\b {\b 8731}}\line (Primary Standard Industrial\line Classification Code Number)}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\b {\b 26-2540421}}\line (I.R.S. Employer\line Identification No.)}\cell \row} \pard {\fs20 {\fs6 \u160?}}\par \pard \qc \sb1 {\fs20 {\b {\b 1055 Westlakes Drive, Suite\u160?300}}}\par \pard \qc \sb1 {\fs20 {\b {\b Berwyn, PA 19312}}}\par \pard \qc \sb1 {\fs20 {\b {\b Attention:}}}\par \pard \qc \sb1 {\fs20 {\b {\b (610)\u160?727-3913}}}\par \pard \qc \sb1 {\fs20 {(Address, including zip code, and telephone number, including area code, of registrant\u8217?s principal executive offices)}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par \pard \qc \sb1 {\fs20 {\b {\b Maria Maccecchini, Ph.D.}}}\par \pard \qc \sb1 {\fs20 {\b {\b President and Chief Executive Officer}}}\par \pard \qc \sb1 {\fs20 {\b {\b Annovis Bio,\u160?Inc.}}}\par \pard \qc \sb1 {\fs20 {\b {\b 1055 Westlakes Drive, Suite\u160?300}}}\par \pard \qc \sb1 {\fs20 {\b {\b Berwyn, PA 19312}}}\par \pard \qc \sb1 {\fs20 {\b {\b (610)\u160?727-3913}}}\par \pard \qc \sb1 {\fs20 {(Name, address, including zip code, and telephone number, including area code, of agent for service)}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}{\*\bkmkstart FIS_UNIDENTIFIED_TABLE_2}{\*\bkmkend FIS_UNIDENTIFIED_TABLE_2}\par \pard \qc \sb1 {\fs20 {\b {\b Copies to:}}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par {\pard\sl-1\par} {\trowd\trleft0\cellx5636 \clvertalb\cellx5885 \cellx11520 \pard \intbl\qc \ri16 {\fs20 {\b {\b Kathleen M. Shay,\u160?Esq.\line Darrick M. Mix,\u160?Esq.}}\line Duane Morris\u160?LLP\line 30 South 17{\fs13 th}\u160?Street\line Philadelphia, Pennsylvania 19103\line (215)\u160?979-1227}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\b {\b William N. Haddad,\u160?Esq.\line Carmen M. Fonda,\u160?Esq.}}\line Venable\u160?LLP\line Rockefeller Center\line 1270 Avenue of the Americas, 24th\u160?Floor\line New York, New York 10020\line (917)\u160?287-1580}\cell \row} \pard {\fs20 {\fs6 \u160?}}\par \pard \qc \sb1 {\fs20 {\b {\b Approximate date of commencement of proposed sale to the public:}}}\par \pard \qc \sb1 {\fs20 {\b {\b As soon as practicable after this Registration Statement is declared effective.}}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par \pard \fi720 \sb1 {\fs20 {If any of the securities being registered on this form are to be offered on a delayed or continuous basis pursuant to Rule\u160?415 under the Securities Act of 1933, check the following box.\u160?} {\f4 o}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par \pard \fi720 \sb1 {\fs20 {If this form is filed to register additional securities for an offering pursuant to Rule\u160?462(b)\u160?under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.\u160?} {\f4 x} 333-232529}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par \pard \fi720 \sb1 {\fs20 {If this form is a post-effective amendment filed pursuant to Rule\u160?462(c)\u160?under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.\u160?} {\f4 o}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par \pard \fi720 \sb1 {\fs20 {If this form is a post-effective amendment filed pursuant to Rule\u160?462(d)\u160?under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.\u160?} {\f4 o}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par \pard \fi720 \sb1 {\fs20 {Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company, or an emerging growth company. See the definitions of \u8220?large accelerated filer,\u8221? \u8220?accelerated filer\u8221? \u8220?smaller reporting company\u8221? and \u8220?emerging growth company\u8221? in Rule\u160?12b-2 of the Exchange Act.}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}{\*\bkmkstart FIS_UNIDENTIFIED_TABLE_3}{\*\bkmkend FIS_UNIDENTIFIED_TABLE_3}\par {\pard\sl-1\par} {\trowd\trleft720\cellx3158 \cellx5377 \cellx8122 \cellx11433 \pard \intbl \ri15 {\fs20 {Large accelerated filer\u160?}{\f4 o}}\cell \pard \intbl \ri16 {\fs20 {Accelerated\u160?filer\u160?}{\f4 o}}\cell \pard \intbl \ri16 {\fs20 {Non-accelerated filer\u160?}{\f4 x}}\cell \pard \intbl \ri16 {\fs20 {Smaller reporting company} {\f4 x}}\cell \row \pard \intbl \ri15 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {Emerging growth company\u160?}{\f4 x}}\cell \row} \pard {\fs20 {\fs6 \u160?}}\par \pard \fi720 \sb1 {\fs20 {If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section\u160?7(a)(2)(B)\u160?of the Securities Act.\u160?}{\f4 x}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}{\*\bkmkstart FIS_REGISTRATION_FEE}{\*\bkmkend FIS_REGISTRATION_FEE}{\*\bkmkstart FIS_UNIDENTIFIED_TABLE_4}{\*\bkmkend FIS_UNIDENTIFIED_TABLE_4}\par \pard \qc \sb1 {\fs20 {\b {\b CALCULATION OF REGISTRATION FEE}}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par {\pard\sl-1\par} {\trowd\trleft1\clbrdrb\brdrdb\brdrw45\brdrcf0\clvertalb\cellx6535 \clbrdrb\brdrdb\brdrw45\brdrcf0\clvertalb\cellx6804 \clbrdrb\brdrdb\brdrw45\brdrcf0\clvertalb\cellx8945 \clbrdrb\brdrdb\brdrw45\brdrcf0\clvertalb\cellx9214 \clbrdrb\brdrdb\brdrw45\brdrcf0\clvertalb\cellx11390 \clbrdrb\brdrdb\brdrw45\brdrcf0\clvertalb\cellx11520 \pard \intbl \ri16 {\fs20 {\b {\fs2\b \u160?}}}\cell \pard \intbl\qc \ri16 {\fs20 {\b {\fs2\b \u160?}}}\cell \pard \intbl\qc \ri36 {\fs20 {\b {\fs2\b \u160?}}}\cell \pard \intbl\qc \ri16 {\fs20 {\b {\fs2\b \u160?}}}\cell \pard \intbl\qc \ri36 {\fs20 {\b {\fs2\b \u160?}}}\cell \pard \intbl\qc \ri16 {\fs20 {\b {\fs2\b \u160?}}}\cell \row} {\trowd\trleft1\clbrdrb\brdrs\brdrw20\brdrcf0\clvertalb\cellx6535 \clbrdrb\brdrs\brdrw20\brdrcf0\clvertalb\cellx6804 \clbrdrb\brdrs\brdrw20\brdrcf0\clvertalb\cellx8945 \clbrdrb\brdrs\brdrw20\brdrcf0\clvertalb\cellx9214 \clbrdrb\brdrs\brdrw20\brdrcf0\clvertalb\cellx11390 \clbrdrb\brdrs\brdrw20\brdrcf0\clvertalb\cellx11520 \pard \intbl\qc \ri16 {\fs20 {\b {\fs16\b Title\u160?of\u160?Each\u160?Class\u160?of\u160?Securities\line to\u160?Be\u160?Registered}}}\cell \pard \intbl\qc \ri16 {\fs20 {\b {\fs2\b \u160?}}}\cell \pard \intbl\qc \ri36 {\fs20 {\b {\fs16\b Proposed\line Maximum\line Aggregate\line Offering\line Price(1)(2)}}}\cell \pard \intbl\qc \ri16 {\fs20 {\b {\fs2\b \u160?}}}\cell \pard \intbl\qc \ri36 {\fs20 {\b {\fs16\b Amount\u160?of\line Registration\line Fee(3)}}}\cell \pard \intbl\qc \ri16 {\fs20 {\b {\fs2\b \u160?}}}\cell \row} {\trowd\trleft1\cellx6535 \clvertalb\cellx6804 \clvertalb\cellx6950 \clvertalb\cellx8945 \clvertalb\cellx9214 \clvertalb\cellx9493 \clvertalb\cellx11390 \clvertalb\cellx11520 \pard \intbl\fi-202 \li202\ri16 {\fs20 {Common Stock, $0.0001 par value per share}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {$}}\cell \pard \intbl\qr \ri16 {\fs20 {3,942,864}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {$}}\cell \pard \intbl\qr \ri16 {\fs20 {511.78}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \row} {\trowd\trleft1\clbrdrb\brdrdb\brdrw45\brdrcf0\cellx6535 \clbrdrb\brdrdb\brdrw45\brdrcf0\clvertalb\cellx6804 \clbrdrb\brdrdb\brdrw45\brdrcf0\clvertalb\cellx8945 \clbrdrb\brdrdb\brdrw45\brdrcf0\clvertalb\cellx9214 \clbrdrb\brdrdb\brdrw45\brdrcf0\clvertalb\cellx11390 \clbrdrb\brdrdb\brdrw45\brdrcf0\clvertalb\cellx11520 \pard \intbl\fi-202 \li202\ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qr \ri36 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qr \ri36 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \row} {\trowd\trleft1\clvertalc\cellx6535 \clvertalc\cellx6804 \clvertalc\cellx6950 \clvertalc\cellx8945 \clvertalc\cellx9214 \clvertalc\cellx9493 \clvertalc\cellx11390 \clvertalc\cellx11520 \pard \intbl\sl-1\vertalc \cell \pard \intbl\sl-1\vertalc \cell \pard \intbl\sl-1\vertalc \cell \pard \intbl\sl-1\vertalc \cell \pard \intbl\sl-1\vertalc \cell \pard \intbl\sl-1\vertalc \cell \pard \intbl\sl-1\vertalc \cell \pard \intbl\sl-1\vertalc \cell \row} \pard \fi-360 \li360 {\fs20 {(1)}{\fs6 \u160?\u160?\u160?\u160?\u160?\u160?\u160?\u160?} Represents only the additional number of shares being registered and includes an additional 85,715 shares issuable upon the exercise of the underwriters\u8217? option to purchase additional shares. Does not include the securities that the registrant previously registered on the Registration Statement on Form\u160?S-1 (File No.\u160?333-232529), as amended (the \u8220?Registration Statement\u8221?).}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par \pard \fi-360 \li360\sb1 {\fs20 {(2)}{\fs6 \u160?\u160?\u160?\u160?\u160?\u160?\u160?\u160?} The registration fee is calculated in accordance with Rule\u160?457(o) under the Securities Act of 1933, as amended (the \u8220?Securities Act\u8221?).}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par \pard \fi-360 \li360\sb1 {\fs20 {(3)}{\fs6 \u160?\u160?\u160?\u160?\u160?\u160?\u160?\u160?} The registrant previously registered 1,642,856 shares of its common stock for which the fee was $1,705.94 on the Registration Statement, which was declared effective by the Securities and Exchange Commission on January\u160?28, 2020. In accordance with Rule\u160?462(b)\u160?under the Securities Act, an additional amount of securities having a proposed maximum aggregate offering price of $3,942,864 is hereby registered.}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par \pard \sb1 {\fs20 {\b {\b This Registration Statement shall become effective upon filing with the Securities and Exchange Commission in accordance with Rule\u160?462(b)\u160?under the Securities Act of 1933, as amended.}}}\par \pard \sb1 {\fs20 {\fs6 \u160?}}\par \pard \sb40 {\fs20 {\fs2 \u160?}}\par \pard \sb80 {\fs20 {\fs6 \u160?}}\par \pard \sb170 \cb1\cbpat1\sl-45\qc {\*\bkmkstart eolPage2}{\*\bkmkend eolPage2}\par \pard \sl-1 \pagebb {\*\bkmkstart FIS_EXPLANATORY_NOTE}{\*\bkmkend FIS_EXPLANATORY_NOTE}\par \pard \qc \sb170 {\fs20 {\u160?}}\par \pard \qc \sb1 {\fs20 {\b {\b EXPLANATORY NOTE AND INCORPORATION BY REFERENCE}}}\par \pard \sb1 {\fs20 {\u160?}}\par \pard \fi720 \sb1 {\fs20 {Pursuant to Rule\u160?462(b)\u160?under the Securities Act of 1933, as amended, Annovis Bio,\u160?Inc., a Delaware corporation (\u8220?Annovis\u8221?), is filing this registration statement with the Securities and Exchange Commission (the \u8220?SEC\u8221?). This registration statement relates to the public offering of securities contemplated by the Registration Statement on\u160?Form\u160?S-1\u160?(File\u160?No.\u160?333-232529)\u160?(the\u160?\u8220?Registration Statement\u8221?) filed by Annovis with the SEC on July\u160?3, 2019, which was declared effective on January\u160?28, 2020.}}\par \pard \sb1 {\fs20 {\u160?}}\par \pard \fi720 \sb1 {\fs20 {Annovis is filing this registration statement for the sole purpose of increasing the aggregate number of shares of common stock, par value $0.0001 per share, offered by Annovis by 657,144 shares, 85,715 of which are subject to purchase upon exercise of the underwriters\u8217? option to purchase additional shares of common stock. The additional shares that are being registered for issuance and sale are in an amount and at a price that together represent no more than 20% of the maximum aggregate offering price set forth in the Calculation of Registration Fee table contained in the Registration Statement. The contents of the Registration Statement, including all amendments and exhibits thereto, are incorporated by reference herein.}}\par \pard \sb1 {\fs20 {\u160?}}\par \pard \fi720 \sb1 {\fs20 {The required opinion and consents are listed on the Exhibit\u160?Index attached hereto and filed herewith.}}\par \pard \sb1 {\fs20 {\u160?}}\par \pard \qc \sb1 {\fs20 2{\*\bkmkstart A19_9635_14S1MEF_HTM_PB_2_062146_3799}{\*\bkmkend A19_9635_14S1MEF_HTM_PB_2_062146_3799}}\par \pard \sb170 \cb1\cbpat1\sl-45\qc {\*\bkmkstart eolPage3}{\*\bkmkend eolPage3}\par \pard \sl-1 \pagebb {\*\bkmkstart FIS_EXHIBIT_INDEX}{\*\bkmkend FIS_EXHIBIT_INDEX}\par \pard \qc \sb170 {\fs20 {\u160?}}\par \pard \qc \sb1 {\fs20 {\b {\b EXHIBIT\u160?INDEX}}}\par \pard \sb1 {\fs20 {\u160?}}{\*\bkmkstart FIS_UNIDENTIFIED_TABLE_5}{\*\bkmkend FIS_UNIDENTIFIED_TABLE_5}\par {\pard\sl-1\par} {\trowd\trleft0\clbrdrb\brdrs\brdrw20\brdrcf0\clvertalb\cellx1167 \clvertalb\cellx1530 \clbrdrb\brdrs\brdrw20\brdrcf0\clvertalb\cellx11520 \pard \intbl \ri16 {\fs20 {\b {\fs16\b Exhibit\line Number}}}\cell \pard \intbl\qc \ri16 {\fs20 {\b {\fs2\b \u160?}}}\cell \pard \intbl\qc \ri16 {\fs20 {\b {\fs16\b Description\u160?of\u160?Exhibit}}}\cell \row} {\trowd\trleft0\cellx1167 \clvertalb\cellx1530 \cellx11520 \pard \intbl\qr \ri16 {\fs20 {5.1}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\field\fldedit{\*\fldinst { HYPERLINK "" \\l "A19_9635_14EX5D1_HTM_EXHIBIT5_1_015032"}}{\fldrslt\ul {{Opinion of Duane Morris\u160?LLP regarding the legality of the securities being registered}}}}}\cell \row \pard \intbl\qr \ri16 {\fs20 {23.1}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\field\fldedit{\*\fldinst { HYPERLINK "" \\l "A19_9635_14EX23D1_HTM_EXHIBIT23_1_071857"}}{\fldrslt\ul {{Consent of WithumSmith+Brown, PC.}}}}}\cell \row \pard \intbl\qr \ri16 {\fs20 {23.2}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\field\fldedit{\*\fldinst { HYPERLINK "" \\l "A19_9635_14EX5D1_HTM_EXHIBIT5_1_015032"}}{\fldrslt\ul {{Consent of Duane Morris\u160?LLP (included in Exhibit\u160?5.1.)}}}}}\cell \row \pard \intbl\qr \ri16 {\fs20 {24.1}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\field\fldedit{\*\fldinst { HYPERLINK "" \\l "A19_9635_14S1MEF_HTM_SIGNATURES_063258"}}{\fldrslt\ul {{Power of Attorney. (Incorporated by reference to Exhibit\u160?24.1 of the Form\u160?S-1 (Registration No.\u160?333-232529) filed on July\u160?3, 2019.)}}}}}\cell \row} \pard \qc {\fs20 {\u160?}}\par \pard \qc \sb1 {\fs20 3{\*\bkmkstart A19_9635_14S1MEF_HTM_PB_3_062352_5992}{\*\bkmkend A19_9635_14S1MEF_HTM_PB_3_062352_5992}}\par \pard \sb170 \cb1\cbpat1\sl-45\qc {\*\bkmkstart eolPage4}{\*\bkmkend eolPage4}\par \pard \sl-1 \pagebb {\*\bkmkstart FIS_SIGNATURES}{\*\bkmkend FIS_SIGNATURES}\par \pard \sb170 {\fs20 {\u160?}}\par \pard \qc \sb1 {\fs20 {\b {\b SIGNATURES}}{\*\bkmkstart A19_9635_14S1MEF_HTM_SIGNATURES_063258}{\*\bkmkend A19_9635_14S1MEF_HTM_SIGNATURES_063258}}\par \pard \sb1 {\fs20 {\u160?}}\par \pard \fi720 \sb1 {\fs20 {Pursuant to the requirements of the Securities Act, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Berwyn, Commonwealth of Pennsylvania, on January\u160?29, 2020.}}\par \pard \qc \sb1 {\fs20 {\u160?}}\par {\pard\sl-1\par} {\trowd\trleft0\cellx5760 \cellx11520 \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri56 {\fs20 {ANNOVIS BIO,\u160?INC.}}\cell \row} {\trowd\trleft0\cellx5760 \cellx6255 \clbrdrb\brdrs\brdrw20\brdrcf0\cellx11520 \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {By:}}\cell \pard \intbl \ri36 {\fs20 {/s/ MARIA MACCECCHINI}}\cell \row} {\trowd\trleft0\cellx5760 \cellx6255 \cellx11520 \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri36 {\fs20 {\u160?}}\cell \row} {\trowd\trleft0\cellx5760 \cellx6255 \cellx7000 \cellx11520 \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {Name:}}\cell \pard \intbl \ri16 {\fs20 {Maria Maccecchini}}\cell \row \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {Title:}}\cell \pard \intbl \ri16 {\fs20 {\i {President and Chief Executive Officer}}}\cell \row} \pard {\fs20 {\u160?}}\par \pard \qc \sb1 {\fs20 {\b {\b SIGNATURES}}}\par \pard \sb1 {\fs20 {\u160?}}\par \pard \fi720 \sb1 {\fs20 {Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities held on the dates indicated.}}\par \pard \sb1 {\fs20 {\u160?}}\par {\pard\sl-1\par} {\trowd\trleft0\clbrdrb\brdrs\brdrw20\brdrcf0\clvertalb\cellx3747 \clvertalb\cellx4024 \clbrdrb\brdrs\brdrw20\brdrcf0\clvertalb\cellx9279 \clvertalb\cellx9556 \clbrdrb\brdrs\brdrw20\brdrcf0\clvertalb\cellx11520 \pard \intbl\qc \ri36 {\fs20 {\b {\fs16\b Signature}}}\cell \pard \intbl\qc \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\b {\fs16\b Title}}}\cell \pard \intbl\qc \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\b {\fs16\b Date}}}\cell \row} {\trowd\trleft0\clbrdrb\brdrs\brdrw20\brdrcf0\cellx3747 \cellx4024 \cellx9279 \cellx9556 \clvertalb\cellx11520 \pard \intbl\qc \ri36 {\fs20 {/s/ MARIA MACCECCHINI}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {President and Chief Executive Officer (principal executive officer)}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {January\u160?29, 2020}}\cell \row} {\trowd\trleft0\cellx3747 \cellx4024 \cellx9279 \cellx9556 \clvertalb\cellx11520 \pard \intbl\qc \ri36 {\fs20 {Maria Maccecchini}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard\intbl\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\fs2 \u160?}}\cell \row \pard \intbl\qc \ri36 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\u160?}}\cell \row} {\trowd\trleft0\clbrdrb\brdrs\brdrw20\brdrcf0\cellx3747 \cellx4024 \cellx9279 \cellx9556 \cellx11520 \pard \intbl\qc \ri36 {\fs20 {/s/ JEFFREY MCGROARTY}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {Chief Financial Officer (principal financial and accounting officer)}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {January\u160?29, 2020}}\cell \row} {\trowd\trleft0\cellx3747 \cellx4024 \cellx9279 \cellx9556 \clvertalb\cellx11520 \pard \intbl\qc \ri36 {\fs20 {Jeffrey McGroarty}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard\intbl\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\fs2 \u160?}}\cell \row \pard \intbl\qc \ri36 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\u160?}}\cell \row \pard \intbl\qc \ri36 {\fs20 {*}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {Chairman of the Board and Director}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {January\u160?29, 2020}}\cell \row \pard \intbl\qc \ri36 {\fs20 {Michael Hoffman}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\fs2 \u160?}}\cell \row \pard \intbl\qc \ri36 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\u160?}}\cell \row \pard \intbl\qc \ri36 {\fs20 {*}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\fs2 \u160?}}\cell \row \pard \intbl\qc \ri36 {\fs20 {Claudine Bruck}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {Director}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {January\u160?29, 2020}}\cell \row \pard \intbl\qc \ri36 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\u160?}}\cell \row \pard \intbl\qc \ri36 {\fs20 {*}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\fs2 \u160?}}\cell \row \pard \intbl\qc \ri36 {\fs20 {Robert Whelan}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {Director}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {January\u160?29, 2020}}\cell \row \pard \intbl\qc \ri36 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\u160?}}\cell \row \pard \intbl\qc \ri36 {\fs20 {*}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\fs2 \u160?}}\cell \row \pard \intbl\qc \ri36 {\fs20 {Mark White}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {Director}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {January\u160?29, 2020}}\cell \row \pard \intbl\qc \ri36 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl \ri16 {\fs20 {\u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\u160?}}\cell \row} {\trowd\trleft0\cellx591 \clbrdrb\brdrs\brdrw20\brdrcf0\cellx3747 \cellx4024 \cellx9279 \cellx9556 \clvertalb\cellx11520 \pard \intbl \ri16 {\fs20 {*By:}}\cell \pard \intbl\qc \ri16 {\fs20 {/s/ MARIA MACCECCHINI}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\fs2 \u160?}}\cell \row} {\trowd\trleft0\cellx591 \cellx3747 \cellx4024 \cellx9279 \cellx9556 \clvertalb\cellx11520 \pard \intbl\qc \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {Maria Maccecchini}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\fs2 \u160?}}\cell \row \pard \intbl\qc \ri16 {\fs20 {\i {\fs2 \u160?}}}\cell \pard \intbl\qc \ri16 {\fs20 {\i {Attorney-in-Fact}}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl \ri16 {\fs20 {\fs2 \u160?}}\cell \pard \intbl\qc \ri16 {\fs20 {\fs2 \u160?}}\cell \row} \pard {\fs20 {\u160?}}\par \pard \qc \sb1 {\fs20 4{\*\bkmkstart A19_9635_14S1MEF_HTM_PB_4_063138_5335}{\*\bkmkend A19_9635_14S1MEF_HTM_PB_4_063138_5335}}\par \pard \sb170 \cb1\cbpat1\sl-45\qc \par \pard \sb170 \sl-1 {\*\bkmkstart eolPage5}{\*\bkmkend eolPage5}{\*\bkmkstart A19_9635_14EX5D1_HTM}{\*\bkmkend A19_9635_14EX5D1_HTM}{\*\bkmkstart FIS_EXHIBIT_5}{\*\bkmkend FIS_EXHIBIT_5}\par {\*\bkmkstart FIS_UNIDENTIFIED_TABLE_6}{\*\bkmkend FIS_UNIDENTIFIED_TABLE_6}\pard \qr \pagebb {\fs20 {\b {\b Exhibit 5.1{\*\bkmkstart A19_9635_14EX5D1_HTM_EXHIBIT5_1_015032}{\*\bkmkend A19_9635_14EX5D1_HTM_EXHIBIT5_1_015032}}}}\par \pard \qc \sb1 {\fs20 {\u160?}}\par {\pard\sl-1\par} {\trowd\trleft0\cellx2533 \cellx7939 \cellx11520 \pard \intbl\qc \li115 {\fs20 {NEW YORK\line LONDON\line SINGAPORE\line PHILADELPHIA\line CHICAGO\line WASHINGTON, DC\line SAN FRANCISCO\line SILICON VALLEY\line SAN DIEGO\line SHANGHAI\line TAIWAN\line BOSTON\line HOUSTON\line LOS ANGELES\line HANOI\line HO CHI MINH CITY}}\cell \pard \intbl\qc \li115 {\fs20 {{\pict\jpegblip\pichgoal540\picwgoal2925\bin2500 JFIF ` ` C $ &%# #"(-90(*6+"#2D26;=@@@&0FKE>J9?@= C =)#)================================================== $ " } !1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w !1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? 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