0001104659-21-103213 8-K 14 20210811 7.01 9.01 20210811 20210811 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 8-K 34 001-39202 211162090 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 8-K 1 tm2124796d1_8k.htm FORM 8-K
0001477845 false 0001477845 2021-08-11 2021-08-11 iso4217:USD xbrli:shares iso4217:USD xbrli:shares

 

 

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

 

 

 

FORM 8-K

 

 

 

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

 

Date of report (Date of earliest event reported): August 11, 2021

 

 

 

ANNOVIS BIO, INC.

(Exact Name of Registrant as Specified in Charter) 

 

 
         
Delaware   001-39202   26-2540421

(State or Other Jurisdiction

of Incorporation)

 

(Commission

File Number)

 

(I.R.S. Employer

Identification No.)

 

1055 Westlakes Drive, Suite 300
Berwyn, PA 19312

(Address of Principal Executive Offices, and Zip Code)

 

(610) 727-3913

Registrant’s Telephone Number, Including Area Code

 

                       Not Applicable                       

(Former Name or Former Address, if Changed Since Last Report) 

 

Securities registered pursuant to Section 12(b) of the Act:

Title of each class Trading Symbol(s) Name of each exchange on which registered
Common Stock, par value $0.0001 per share ANVS NYSE American

 

 

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

 

  ¨ Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

 

  ¨ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

 

  ¨ Pre-commencement communication pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

 

¨Pre-commencement communication pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

 

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2).

 

Emerging growth company x

 

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. x

 

 

 

 

 

 

Item 7.01 Regulation FD Disclosure.

 

On August 11, 2021, Annovis Bio Inc. (the “Company”) posted on its website at www.annovisbio.com under “Investors & Media” frequently asked questions related to recent interim results among both Alzheimer’s disease (AD) and Parkinson’s disease (PD) patients from Phase 2a clinical trials of the Company’s lead compound, ANVS401. A copy of the frequently asked questions is furnished as Exhibit 99.1.

 

The information in this Item 7.01, Item 9.01 and Exhibit 99.1 attached hereto shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, or otherwise subject to the liability of such section, nor shall it be deemed incorporated by reference in any filing of the Company under the Securities Act of 1933 or the Securities Exchange Act of 1934, regardless of any general incorporation language in such filing, unless expressly incorporated by specific reference in such filing.

 

Cautionary Statement Regarding Forward-Looking Information

 

This current report on Form 8-K contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. All statements other than those of historical fact in the frequently asked questions documents are forward-looking statements. Forward-looking statements may be identified by terminology such as “believe,” “anticipate,” “plan,” “may,” “intend,” “will,” “should,” “expect,” “estimate,” “potential” and “continue” and similar expressions, including the negative of these words, but not all forward-looking statements contain these words. Forward-looking statements include, but are not limited to, statements regarding the Company’s expectations and timelines regarding the Company’s Phase 2a clinical trial and expectations regarding current or future clinical trials. Forward-looking statements are based on the Company’s current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. Actual results could differ materially from those described or implied by such forward-looking statements as a result of various important factors, including, without limitation, the failure of preliminary data to predict final study results and impacts from the COVID-19 pandemic and the other important factors other risks and uncertainties are described more fully in the section titled “Risk Factors” in the Annual Report on Form 10-K for the year ended December 31, 2020 filed with the Securities and Exchange Commission (“SEC”) and elsewhere in our filings and reports with the SEC. Forward-looking statements speak as of the date they are made, and the Company undertakes no obligation to update them except as may be required under applicable law.

 

Item 9.01 Financial Statements and Exhibits.

 

(d)  Exhibits.

 

Exhibit
Number

 

Description

99.1   Frequently Asked Questions - Annovis Bio Phase 2a Data Results (furnished herewith).
104   Cover Page Interactive Data File (embedded within the Inline XBRL document).

 

 

 

SIGNATURES

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

  ANNOVIS BIO, INC.
     
Date: August 11, 2021 By:

/s/ Jeffrey McGroarty

    Name: Jeffrey McGroarty
    Title: Chief Financial Officer

 

 

 

 

 

 

EX-99.1 2 tm2124796d1_ex99-1.htm EXHIBIT 99.1

 

Exhibit 99.1

 

Frequently Asked Questions

Annovis Bio Phase 2a Data Results

 

1.What interim results from the Phase 2a study of ANVS401 were recently announced by Annovis Bio? Why did some people believe the company’s recent interim data readout was negative?

 

Answer: On July 28, we announced interim results among both Alzheimer’s disease (AD) and Parkinson’s disease (PD) patients from Phase 2a clinical trials of our lead compound, ANVS401 (Posiphen).

 

The results were positive – over the first 25 days of treatment, the initial patient cohorts demonstrated statistically significant positive results in both cognitive and motor skills. The biomarkers presented and analyzed also corroborated the efficacy of ANVS401.

 

We are aware that some initial reporting after our presentation at the AAIC 2021 conference included an error in which the scores of the WAIS test were transposed between placebo and treated PD patients. We have received a number of questions regarding this error and believe it led some people to conclude that the placebo was more effective than treatment with ANVS401, which is incorrect.

 

2.Explain what is statistically significant in drug development?

 

Answer: Statistical significance separates random events from events that are caused by a specific intervention. The FDA looks at a drug as being effective if the efficacy measured has a less than 5% chance (p<0.05) of being due to the random daily behavior of patients. If the effect observed has a greater than 5% chance (p>0.05) of being due to random behavior, then it is called non statistically significant and it means that the drug did not affect treated patients.

 

In the case of ANVS401 we saw statistically significant changes (p<0.05) in ADAS-Cog11, MDS-UPDRS and WAIS, showing efficacy of the drug in AD and PD patents.

 

We also showed non statistically significant data in the mini mental state examination (MMSE) and clinical dementia rating sum of boxes (CDR), reflecting that the scores were due to random changes in behavior.

 

3.What does the WAIS Scale measure; and what did the scale reveal in the Phase 2a data?

 

Answer: The WAIS coding scale measures visual-motor dexterity, associative nonverbal learning, and nonverbal short-term memory. It measures fine-motor dexterity, speed, accuracy, and ability to manipulate a pencil and perceptual organization.

 

 

 

4.How did the Parkinson’s disease patients score using the WAIS test?

 

Answer: After 25 days of treating PD patients with 80 mg a day of ANVS401, the speed and accuracy of the patients is faster than at baseline (6.1 points, p<0.05) and faster than the placebo treated group (9.8 points, p<0.05). Both scores are statistically significantly better in the treated group, whether compared to baseline or to placebo.

Chart, waterfall chart

Description automatically generated

 

5.How did the Alzheimer’s disease patients score using the WAIS test?

 

Answer: After 25 days of treating AD patients with 80 mg a day of ANVS401, the speed of the treated group is faster than at baseline, and the patients on average coded 6.6 more correct fields. The improvement in treated AD patients compared to baseline was statistically significant. At 25 days, the placebo group improved slightly, but not as much as the ANVS401 treated group.

 

6.Is the Phase 2a data from the WAIS statistically significant?

 

Answer: Yes, the outcome of the WAIS coding test is statistically significant and confirms the statistical significance of the ADAS-Cog11 and MDS-UPDRS tests in both AD and PD patients.

 

 

 

7.How did the AD and PD patients fare on the MMSE, and CDR?

 

Answer: This study was planned with the primary endpoints being biomarkers. The fact that we saw cognitive and functional improvement is an additional benefit.

 

We saw statistically significant improvements in the ADAS-Cog11, MDS-UPDRS, and in the WAIS tests and not statistically significant results in the MMSE and CDR.

 

While we conducted all of these tests to look at a full cognition panel, we did not necessarily expect the MMSE and CDR to change, because while the ADAS-Cog11 and MDS-UPDRS are nimble tests that can show a change in a short period of time, the MMSE and CDR are less sensitive and generally would not be expected to change in one month.

 

8.Did the placebo outperform ANVS401 in the MMSE and CDR tests?

 

Answer: No, the changes in patients in the MMSE and CDR tests were not statistically significant, which is interpreted to mean that the difference is due to randomness and not to the effect of the drug, whereas statistical significance means that the change is due to the effect of the drug.

 

9.Why is Annovis Bio’s Phase 2a cytotoxic cascade data important?

 

Answer: The cytotoxic cascade data is important because chronic brain insults lead to high levels of neurotoxic proteins, that cause impairment in the axonal transport, inflammation, and nerve cell death, and ultimately impair a patient’s cognition and/or movement.

 

10.Did the Phase 2a data reveal ANVS401 lowered levels of neurotoxic proteins in AD and PD patients?

 

Answer: Yes, the Phase 2a data revealed ANVS401 lowered levels of neurotoxic proteins for both AD and PD patients and improved cognition and motor function. The data also revealed significant reductions of neurotoxic proteins levels and inflammation, as well as biomarkers for axonal damage, and highlighted the efficacy data. Our data reveals ANVS401 improves axonal transport in vitro and in vivo, and by doing so restores normal brain function.

 

11.What is the take-home message of the first 28 patients treated with ANVS401?

 

Answer: ANVS401 showed that it improved cognition in Alzheimer’s disease, as measured by ADAS-Cog11 and WAIS assessment scales. ANVS401 improved movement in Parkinson’s disease patients as measured by MDS-UPDRS and WAIS. The efficacy data is corroborated by the biomarkers of the toxic cascade that all point in the direction of an improvement in AD and PD.

 

 

 

This is the first double-blind placebo-controlled study ever conducted of which we are aware that shows cognitive improvement in AD and functional improvement in PD patients by the same therapy.

 

Cautionary Statement Regarding Forward-Looking Information

 

The foregoing frequently asked questions contain “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. All statements other than those of historical fact in the frequently asked questions documents are forward-looking statements. Forward-looking statements may be identified by terminology such as “believe,” “anticipate,” “plan,” “may,” “intend,” “will,” “should,” “expect,” “estimate,” “potential” and “continue” and similar expressions, including the negative of these words, but not all forward-looking statements contain these words. Forward-looking statements include, but are not limited to, statements regarding Annovis Bio’s expectations and timelines regarding Annovis Bio’s Phase 2a clinical trial and expectations regarding current or future clinical trials. Forward-looking statements are based on Annovis Bio’s current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. Actual results could differ materially from those described or implied by such forward-looking statements as a result of various important factors, including, without limitation, the failure of preliminary data to predict final study results and impacts from the COVID-19 pandemic and the other important factors other risks and uncertainties are described more fully in the section titled “Risk Factors” in the Annual Report on Form 10-K for the year ended December 31, 2020 filed with the Securities and Exchange Commission (“SEC”) and elsewhere in our filings and reports with the SEC. Forward-looking statements speak as of the date they are made, and Annovis Bio undertakes no obligation to update them except as may be required under applicable law.

 

 

 

 

EX-101.SCH 3 anvs-20210811.xsd XBRL TAXONOMY EXTENSION SCHEMA 00000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink EX-101.LAB 4 anvs-20210811_lab.xml XBRL TAXONOMY EXTENSION LABEL LINKBASE Cover [Abstract] Document Type Amendment Flag Amendment Description Document Registration Statement Document Annual Report Document Quarterly Report Document Transition Report Document Shell Company Report Document Shell Company Event Date Document Period Start Date Document Period End Date Document Fiscal Period Focus Document Fiscal Year Focus Current Fiscal Year End Date Entity File Number Entity Registrant Name Entity Central Index Key Entity Primary SIC Number Entity Tax Identification Number Entity Incorporation, State or Country Code Entity Address, Address Line One Entity Address, Address Line Two Entity Address, Address Line Three Entity Address, City or Town Entity Address, State or Province Entity Address, Country Entity Address, Postal Zip Code Country Region City Area Code Local Phone Number Extension Written Communications Soliciting Material Pre-commencement Tender Offer Pre-commencement Issuer Tender Offer Title of 12(b) Security No Trading Symbol Flag Trading Symbol Security Exchange Name Title of 12(g) Security Security Reporting Obligation Annual Information Form Audited Annual Financial Statements Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Interactive Data Current Entity Filer Category Entity Small Business Entity Emerging Growth Company Elected Not To Use the Extended Transition Period Document Accounting Standard Other Reporting Standard Item Number Entity Shell Company Entity Public Float Entity Bankruptcy Proceedings, Reporting Current Entity Common Stock, Shares Outstanding Documents Incorporated by Reference [Text Block] EX-101.PRE 5 anvs-20210811_pre.xml XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE GRAPHIC 6 tm2124796d1_ex99-img001.jpg GRAPHIC begin 644 tm2124796d1_ex99-img001.jpg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end XML 7 tm2124796d1_8k_htm.xml IDEA: XBRL DOCUMENT 0001477845 2021-08-11 2021-08-11 iso4217:USD shares iso4217:USD shares 0001477845 false 8-K 2021-08-11 ANNOVIS BIO, INC. DE 001-39202 26-2540421 1055 Westlakes Drive Suite 300 Berwyn PA 19312 610 727-3913 Common Stock, par value $0.0001 per share ANVS NYSEAMER false false false false true true XML 8 R1.htm IDEA: XBRL DOCUMENT v3.21.2
Cover
Aug. 11, 2021
Cover [Abstract]  
Document Type 8-K
Amendment Flag false
Document Period End Date Aug. 11, 2021
Entity File Number 001-39202
Entity Registrant Name ANNOVIS BIO, INC.
Entity Central Index Key 0001477845
Entity Tax Identification Number 26-2540421
Entity Incorporation, State or Country Code DE
Entity Address, Address Line One 1055 Westlakes Drive
Entity Address, Address Line Two Suite 300
Entity Address, City or Town Berwyn
Entity Address, State or Province PA
Entity Address, Postal Zip Code 19312
City Area Code 610
Local Phone Number 727-3913
Written Communications false
Soliciting Material false
Pre-commencement Tender Offer false
Pre-commencement Issuer Tender Offer false
Title of 12(b) Security Common Stock, par value $0.0001 per share
Trading Symbol ANVS
Security Exchange Name NYSEAMER
Entity Emerging Growth Company true
Elected Not To Use the Extended Transition Period true
EXCEL 9 Financial_Report.xlsx IDEA: XBRL DOCUMENT begin 644 Financial_Report.xlsx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end XML 10 Show.js IDEA: XBRL DOCUMENT // Edgar(tm) Renderer was created by staff of the U.S. Securities and Exchange Commission. Data and content created by government employees within the scope of their employment are not subject to domestic copyright protection. 17 U.S.C. 105. var Show={};Show.LastAR=null,Show.showAR=function(a,r,w){if(Show.LastAR)Show.hideAR();var e=a;while(e&&e.nodeName!='TABLE')e=e.nextSibling;if(!e||e.nodeName!='TABLE'){var ref=((window)?w.document:document).getElementById(r);if(ref){e=ref.cloneNode(!0); e.removeAttribute('id');a.parentNode.appendChild(e)}} if(e)e.style.display='block';Show.LastAR=e};Show.hideAR=function(){Show.LastAR.style.display='none'};Show.toggleNext=function(a){var e=a;while(e.nodeName!='DIV')e=e.nextSibling;if(!e.style){}else if(!e.style.display){}else{var d,p_;if(e.style.display=='none'){d='block';p='-'}else{d='none';p='+'} e.style.display=d;if(a.textContent){a.textContent=p+a.textContent.substring(1)}else{a.innerText=p+a.innerText.substring(1)}}} XML 11 report.css IDEA: XBRL DOCUMENT /* Updated 2009-11-04 */ /* v2.2.0.24 */ /* DefRef Styles */ .report table.authRefData{ background-color: #def; border: 2px solid #2F4497; font-size: 1em; position: absolute; } .report table.authRefData a { display: block; font-weight: bold; } .report table.authRefData p { margin-top: 0px; } .report table.authRefData .hide { background-color: #2F4497; padding: 1px 3px 0px 0px; text-align: right; } .report table.authRefData .hide a:hover { background-color: #2F4497; } .report table.authRefData .body { height: 150px; overflow: auto; width: 400px; } .report table.authRefData table{ font-size: 1em; } /* Report Styles */ .pl a, .pl a:visited { color: black; text-decoration: none; } /* table */ .report { background-color: white; border: 2px solid #acf; clear: both; color: black; font: normal 8pt Helvetica, Arial, san-serif; margin-bottom: 2em; } .report hr { border: 1px solid #acf; } /* Top labels */ .report th { background-color: #acf; color: black; font-weight: bold; text-align: center; } .report th.void { background-color: transparent; color: #000000; font: bold 10pt Helvetica, Arial, san-serif; text-align: left; } .report .pl { text-align: left; vertical-align: top; white-space: normal; width: 200px; white-space: normal; /* word-wrap: break-word; */ } .report td.pl a.a { cursor: pointer; display: block; width: 200px; overflow: hidden; } .report td.pl div.a { width: 200px; } .report td.pl a:hover { background-color: #ffc; } /* Header rows... */ .report tr.rh { background-color: #acf; color: black; font-weight: bold; } /* Calendars... */ .report .rc { background-color: #f0f0f0; } /* Even rows... */ .report .re, .report .reu { background-color: #def; } .report .reu td { border-bottom: 1px solid black; } /* Odd rows... */ .report .ro, .report .rou { background-color: white; } .report .rou td { border-bottom: 1px solid black; } .report .rou table td, .report .reu table td { border-bottom: 0px solid black; } /* styles for footnote marker */ .report .fn { white-space: nowrap; } /* styles for numeric types */ .report .num, .report .nump { text-align: right; white-space: nowrap; } .report .nump { padding-left: 2em; } .report .nump { padding: 0px 0.4em 0px 2em; } /* styles for text types */ .report .text { text-align: left; white-space: normal; } .report .text .big { margin-bottom: 1em; width: 17em; } .report .text .more { display: none; } .report .text .note { font-style: italic; font-weight: bold; } .report .text .small { width: 10em; } .report sup { font-style: italic; } .report .outerFootnotes { font-size: 1em; } XML 12 FilingSummary.xml IDEA: XBRL DOCUMENT 3.21.2 html 1 96 1 false 0 0 false 3 false false R1.htm 00000001 - Document - Cover Sheet http://annovisbio.com/role/Cover Cover Cover 1 false false All Reports Book All Reports tm2124796d1_8k.htm anvs-20210811.xsd anvs-20210811_lab.xml anvs-20210811_pre.xml tm2124796d1_ex99-1.htm http://xbrl.sec.gov/dei/2020-01-31 true false JSON 14 MetaLinks.json IDEA: XBRL DOCUMENT { "instance": { "tm2124796d1_8k.htm": { "axisCustom": 0, "axisStandard": 0, "contextCount": 1, "dts": { "definitionLink": { "remote": [ "http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-eedm-def-2020-01-31.xml", "http://xbrl.fasb.org/srt/2020/elts/srt-eedm1-def-2020-01-31.xml" ] }, "inline": { "local": [ "tm2124796d1_8k.htm" ] }, "labelLink": { "local": [ "anvs-20210811_lab.xml" ], "remote": [ "https://xbrl.sec.gov/dei/2020/dei-doc-2020-01-31.xml" ] }, "presentationLink": { "local": [ "anvs-20210811_pre.xml" ] }, "referenceLink": { "remote": [ "https://xbrl.sec.gov/dei/2020/dei-ref-2020-01-31.xml" ] }, "schema": { "local": [ "anvs-20210811.xsd" ], "remote": [ "http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd", "http://www.xbrl.org/2003/xl-2003-12-31.xsd", "http://www.xbrl.org/2003/xlink-2003-12-31.xsd", "https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd", "http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd", "http://www.xbrl.org/2005/xbrldt-2005.xsd", "http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd", "http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd", "http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd", "http://www.xbrl.org/lrr/role/net-2009-12-16.xsd", "http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd", "http://xbrl.fasb.org/us-gaap/2020/elts/us-roles-2020-01-31.xsd", "http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd", "http://www.xbrl.org/2006/ref-2006-02-27.xsd", "http://xbrl.fasb.org/srt/2020/elts/srt-types-2020-01-31.xsd", "http://xbrl.fasb.org/srt/2020/elts/srt-roles-2020-01-31.xsd", "https://xbrl.sec.gov/country/2020/country-2020-01-31.xsd", "http://xbrl.fasb.org/us-gaap/2020/elts/us-types-2020-01-31.xsd", "http://www.xbrl.org/lrr/role/deprecated-2009-12-16.xsd" ] } }, "elementCount": 59, "entityCount": 1, "hidden": { "http://xbrl.sec.gov/dei/2020-01-31": 2, "total": 2 }, "keyCustom": 0, "keyStandard": 96, "memberCustom": 0, "memberStandard": 0, "nsprefix": "ANVS", "nsuri": "http://annovisbio.com/20210811", "report": { "R1": { "firstAnchor": { "ancestors": [ "span", "b", "span", "p", "body", "html" ], "baseRef": "tm2124796d1_8k.htm", "contextRef": "From2021-08-11to2021-08-11", "decimals": null, "first": true, "lang": "en-US", "name": "dei:DocumentType", "reportCount": 1, "unique": true, "unitRef": null, "xsiNil": "false" }, "groupType": "document", "isDefault": "true", "longName": "00000001 - Document - Cover", "role": "http://annovisbio.com/role/Cover", "shortName": "Cover", "subGroupType": "", "uniqueAnchor": { "ancestors": [ "span", "b", "span", "p", "body", "html" ], "baseRef": "tm2124796d1_8k.htm", "contextRef": "From2021-08-11to2021-08-11", "decimals": null, "first": true, "lang": "en-US", "name": "dei:DocumentType", "reportCount": 1, "unique": true, "unitRef": null, "xsiNil": "false" } } }, "segmentCount": 0, "tag": { "dei_AmendmentDescription": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Description of changes contained within amended document.", "label": "Amendment Description" } } }, "localname": "AmendmentDescription", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "stringItemType" }, "dei_AmendmentFlag": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.", "label": "Amendment Flag" } } }, "localname": "AmendmentFlag", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_AnnualInformationForm": { "auth_ref": [ "r12" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag with value true on a form if it is an annual report containing an annual information form.", "label": "Annual Information Form" } } }, "localname": "AnnualInformationForm", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_AuditedAnnualFinancialStatements": { "auth_ref": [ "r12" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag with value true on a form if it is an annual report containing audited financial statements.", "label": "Audited Annual Financial Statements" } } }, "localname": "AuditedAnnualFinancialStatements", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_CityAreaCode": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Area code of city", "label": "City Area Code" } } }, "localname": "CityAreaCode", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "normalizedStringItemType" }, "dei_CountryRegion": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Region code of country", "label": "Country Region" } } }, "localname": "CountryRegion", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "normalizedStringItemType" }, "dei_CoverAbstract": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Cover page.", "label": "Cover [Abstract]" } } }, "localname": "CoverAbstract", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "xbrltype": "stringItemType" }, "dei_CurrentFiscalYearEndDate": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "End date of current fiscal year in the format --MM-DD.", "label": "Current Fiscal Year End Date" } } }, "localname": "CurrentFiscalYearEndDate", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "gMonthDayItemType" }, "dei_DocumentAccountingStandard": { "auth_ref": [ "r11" ], "lang": { "en-us": { "role": { "documentation": "The basis of accounting the registrant has used to prepare the financial statements included in this filing This can either be 'U.S. GAAP', 'International Financial Reporting Standards', or 'Other'.", "label": "Document Accounting Standard" } } }, "localname": "DocumentAccountingStandard", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "accountingStandardItemType" }, "dei_DocumentAnnualReport": { "auth_ref": [ "r9", "r11", "r12" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true only for a form used as an annual report.", "label": "Document Annual Report" } } }, "localname": "DocumentAnnualReport", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_DocumentFiscalPeriodFocus": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Fiscal period values are FY, Q1, Q2, and Q3. 1st, 2nd and 3rd quarter 10-Q or 10-QT statements have value Q1, Q2, and Q3 respectively, with 10-K, 10-KT or other fiscal year statements having FY.", "label": "Document Fiscal Period Focus" } } }, "localname": "DocumentFiscalPeriodFocus", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "fiscalPeriodItemType" }, "dei_DocumentFiscalYearFocus": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "This is focus fiscal year of the document report in YYYY format. For a 2006 annual report, which may also provide financial information from prior periods, fiscal 2006 should be given as the fiscal year focus. Example: 2006.", "label": "Document Fiscal Year Focus" } } }, "localname": "DocumentFiscalYearFocus", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "gYearItemType" }, "dei_DocumentPeriodEndDate": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "The end date of the period reflected on the cover page if a periodic report. For all other reports and registration statements containing historical data, it is the date up through which that historical data is presented. If there is no historical data in the report, use the filing date. The format of the date is YYYY-MM-DD.", "label": "Document Period End Date" } } }, "localname": "DocumentPeriodEndDate", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "dateItemType" }, "dei_DocumentPeriodStartDate": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "The start date of the period covered in the document, in YYYY-MM-DD format.", "label": "Document Period Start Date" } } }, "localname": "DocumentPeriodStartDate", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "dateItemType" }, "dei_DocumentQuarterlyReport": { "auth_ref": [ "r10" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true only for a form used as an quarterly report.", "label": "Document Quarterly Report" } } }, "localname": "DocumentQuarterlyReport", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_DocumentRegistrationStatement": { "auth_ref": [ "r18" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true only for a form used as a registration statement.", "label": "Document Registration Statement" } } }, "localname": "DocumentRegistrationStatement", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_DocumentShellCompanyEventDate": { "auth_ref": [ "r11" ], "lang": { "en-us": { "role": { "documentation": "Date of event requiring a shell company report.", "label": "Document Shell Company Event Date" } } }, "localname": "DocumentShellCompanyEventDate", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "dateItemType" }, "dei_DocumentShellCompanyReport": { "auth_ref": [ "r11" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true for a Shell Company Report pursuant to section 13 or 15(d) of the Exchange Act.", "label": "Document Shell Company Report" } } }, "localname": "DocumentShellCompanyReport", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_DocumentTransitionReport": { "auth_ref": [ "r13" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true only for a form used as a transition report.", "label": "Document Transition Report" } } }, "localname": "DocumentTransitionReport", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_DocumentType": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.", "label": "Document Type" } } }, "localname": "DocumentType", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "submissionTypeItemType" }, "dei_DocumentsIncorporatedByReferenceTextBlock": { "auth_ref": [ "r1" ], "lang": { "en-us": { "role": { "documentation": "Documents incorporated by reference.", "label": "Documents Incorporated by Reference [Text Block]" } } }, "localname": "DocumentsIncorporatedByReferenceTextBlock", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "textBlockItemType" }, "dei_EntityAddressAddressLine1": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Address Line 1 such as Attn, Building Name, Street Name", "label": "Entity Address, Address Line One" } } }, "localname": "EntityAddressAddressLine1", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityAddressAddressLine2": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Address Line 2 such as Street or Suite number", "label": "Entity Address, Address Line Two" } } }, "localname": "EntityAddressAddressLine2", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityAddressAddressLine3": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Address Line 3 such as an Office Park", "label": "Entity Address, Address Line Three" } } }, "localname": "EntityAddressAddressLine3", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityAddressCityOrTown": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Name of the City or Town", "label": "Entity Address, City or Town" } } }, "localname": "EntityAddressCityOrTown", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityAddressCountry": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "ISO 3166-1 alpha-2 country code.", "label": "Entity Address, Country" } } }, "localname": "EntityAddressCountry", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "countryCodeItemType" }, "dei_EntityAddressPostalZipCode": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Code for the postal or zip code", "label": "Entity Address, Postal Zip Code" } } }, "localname": "EntityAddressPostalZipCode", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityAddressStateOrProvince": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Name of the state or province.", "label": "Entity Address, State or Province" } } }, "localname": "EntityAddressStateOrProvince", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "stateOrProvinceItemType" }, "dei_EntityBankruptcyProceedingsReportingCurrent": { "auth_ref": [ "r4" ], "lang": { "en-us": { "role": { "documentation": "For registrants involved in bankruptcy proceedings during the preceding five years, the value Yes indicates that the registrant has filed all documents and reports required to be filed by Section 12, 13 or 15(d) of the Securities Exchange Act of 1934 subsequent to the distribution of securities under a plan confirmed by a court; the value No indicates the registrant has not. Registrants not involved in bankruptcy proceedings during the preceding five years should not report this element.", "label": "Entity Bankruptcy Proceedings, Reporting Current" } } }, "localname": "EntityBankruptcyProceedingsReportingCurrent", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_EntityCentralIndexKey": { "auth_ref": [ "r14" ], "lang": { "en-us": { "role": { "documentation": "A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.", "label": "Entity Central Index Key" } } }, "localname": "EntityCentralIndexKey", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "centralIndexKeyItemType" }, "dei_EntityCommonStockSharesOutstanding": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Indicate number of shares or other units outstanding of each of registrant's classes of capital or common stock or other ownership interests, if and as stated on cover of related periodic report. Where multiple classes or units exist define each class/interest by adding class of stock items such as Common Class A [Member], Common Class B [Member] or Partnership Interest [Member] onto the Instrument [Domain] of the Entity Listings, Instrument.", "label": "Entity Common Stock, Shares Outstanding" } } }, "localname": "EntityCommonStockSharesOutstanding", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "sharesItemType" }, "dei_EntityCurrentReportingStatus": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Indicate 'Yes' or 'No' whether registrants (1) have filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that registrants were required to file such reports), and (2) have been subject to such filing requirements for the past 90 days. This information should be based on the registrant's current or most recent filing containing the related disclosure.", "label": "Entity Current Reporting Status" } } }, "localname": "EntityCurrentReportingStatus", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "yesNoItemType" }, "dei_EntityEmergingGrowthCompany": { "auth_ref": [ "r14" ], "lang": { "en-us": { "role": { "documentation": "Indicate if registrant meets the emerging growth company criteria.", "label": "Entity Emerging Growth Company" } } }, "localname": "EntityEmergingGrowthCompany", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_EntityExTransitionPeriod": { "auth_ref": [ "r17" ], "lang": { "en-us": { "role": { "documentation": "Indicate if an emerging growth company has elected not to use the extended transition period for complying with any new or revised financial accounting standards.", "label": "Elected Not To Use the Extended Transition Period" } } }, "localname": "EntityExTransitionPeriod", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_EntityFileNumber": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.", "label": "Entity File Number" } } }, "localname": "EntityFileNumber", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "fileNumberItemType" }, "dei_EntityFilerCategory": { "auth_ref": [ "r14" ], "lang": { "en-us": { "role": { "documentation": "Indicate whether the registrant is one of the following: Large Accelerated Filer, Accelerated Filer, Non-accelerated Filer. Definitions of these categories are stated in Rule 12b-2 of the Exchange Act. This information should be based on the registrant's current or most recent filing containing the related disclosure.", "label": "Entity Filer Category" } } }, "localname": "EntityFilerCategory", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "filerCategoryItemType" }, "dei_EntityIncorporationStateCountryCode": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Two-character EDGAR code representing the state or country of incorporation.", "label": "Entity Incorporation, State or Country Code" } } }, "localname": "EntityIncorporationStateCountryCode", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "edgarStateCountryItemType" }, "dei_EntityInteractiveDataCurrent": { "auth_ref": [ "r15" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true when the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).", "label": "Entity Interactive Data Current" } } }, "localname": "EntityInteractiveDataCurrent", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "yesNoItemType" }, "dei_EntityPrimarySicNumber": { "auth_ref": [ "r12" ], "lang": { "en-us": { "role": { "documentation": "Primary Standard Industrial Classification (SIC) Number for the Entity.", "label": "Entity Primary SIC Number" } } }, "localname": "EntityPrimarySicNumber", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "sicNumberItemType" }, "dei_EntityPublicFloat": { "auth_ref": [], "crdr": "credit", "lang": { "en-us": { "role": { "documentation": "The aggregate market value of the voting and non-voting common equity held by non-affiliates computed by reference to the price at which the common equity was last sold, or the average bid and asked price of such common equity, as of the last business day of the registrant's most recently completed second fiscal quarter.", "label": "Entity Public Float" } } }, "localname": "EntityPublicFloat", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "monetaryItemType" }, "dei_EntityRegistrantName": { "auth_ref": [ "r14" ], "lang": { "en-us": { "role": { "documentation": "The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.", "label": "Entity Registrant Name" } } }, "localname": "EntityRegistrantName", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityShellCompany": { "auth_ref": [ "r14" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true when the registrant is a shell company as defined in Rule 12b-2 of the Exchange Act.", "label": "Entity Shell Company" } } }, "localname": "EntityShellCompany", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_EntitySmallBusiness": { "auth_ref": [ "r14" ], "lang": { "en-us": { "role": { "documentation": "Indicates that the company is a Smaller Reporting Company (SRC).", "label": "Entity Small Business" } } }, "localname": "EntitySmallBusiness", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_EntityTaxIdentificationNumber": { "auth_ref": [ "r14" ], "lang": { "en-us": { "role": { "documentation": "The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.", "label": "Entity Tax Identification Number" } } }, "localname": "EntityTaxIdentificationNumber", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "employerIdItemType" }, "dei_EntityVoluntaryFilers": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Indicate 'Yes' or 'No' if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.", "label": "Entity Voluntary Filers" } } }, "localname": "EntityVoluntaryFilers", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "yesNoItemType" }, "dei_EntityWellKnownSeasonedIssuer": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Indicate 'Yes' or 'No' if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Is used on Form Type: 10-K, 10-Q, 8-K, 20-F, 6-K, 10-K/A, 10-Q/A, 20-F/A, 6-K/A, N-CSR, N-Q, N-1A.", "label": "Entity Well-known Seasoned Issuer" } } }, "localname": "EntityWellKnownSeasonedIssuer", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "yesNoItemType" }, "dei_Extension": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Extension number for local phone number.", "label": "Extension" } } }, "localname": "Extension", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "normalizedStringItemType" }, "dei_LocalPhoneNumber": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Local phone number for entity.", "label": "Local Phone Number" } } }, "localname": "LocalPhoneNumber", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "normalizedStringItemType" }, "dei_NoTradingSymbolFlag": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true only for a security having no trading symbol.", "label": "No Trading Symbol Flag" } } }, "localname": "NoTradingSymbolFlag", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_OtherReportingStandardItemNumber": { "auth_ref": [ "r11" ], "lang": { "en-us": { "role": { "documentation": "\"Item 17\" or \"Item 18\" specified when the basis of accounting is neither US GAAP nor IFRS.", "label": "Other Reporting Standard Item Number" } } }, "localname": "OtherReportingStandardItemNumber", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "otherReportingStandardItemNumberItemType" }, "dei_PreCommencementIssuerTenderOffer": { "auth_ref": [ "r5" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.", "label": "Pre-commencement Issuer Tender Offer" } } }, "localname": "PreCommencementIssuerTenderOffer", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_PreCommencementTenderOffer": { "auth_ref": [ "r6" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.", "label": "Pre-commencement Tender Offer" } } }, "localname": "PreCommencementTenderOffer", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_Security12bTitle": { "auth_ref": [ "r0" ], "lang": { "en-us": { "role": { "documentation": "Title of a 12(b) registered security.", "label": "Title of 12(b) Security" } } }, "localname": "Security12bTitle", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "securityTitleItemType" }, "dei_Security12gTitle": { "auth_ref": [ "r3" ], "lang": { "en-us": { "role": { "documentation": "Title of a 12(g) registered security.", "label": "Title of 12(g) Security" } } }, "localname": "Security12gTitle", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "securityTitleItemType" }, "dei_SecurityExchangeName": { "auth_ref": [ "r2" ], "lang": { "en-us": { "role": { "documentation": "Name of the Exchange on which a security is registered.", "label": "Security Exchange Name" } } }, "localname": "SecurityExchangeName", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "edgarExchangeCodeItemType" }, "dei_SecurityReportingObligation": { "auth_ref": [ "r7" ], "lang": { "en-us": { "role": { "documentation": "15(d), indicating whether the security has a reporting obligation under that section of the Exchange Act.", "label": "Security Reporting Obligation" } } }, "localname": "SecurityReportingObligation", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "securityReportingObligationItemType" }, "dei_SolicitingMaterial": { "auth_ref": [ "r8" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.", "label": "Soliciting Material" } } }, "localname": "SolicitingMaterial", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" }, "dei_TradingSymbol": { "auth_ref": [], "lang": { "en-us": { "role": { "documentation": "Trading symbol of an instrument as listed on an exchange.", "label": "Trading Symbol" } } }, "localname": "TradingSymbol", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "tradingSymbolItemType" }, "dei_WrittenCommunications": { "auth_ref": [ "r16" ], "lang": { "en-us": { "role": { "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.", "label": "Written Communications" } } }, "localname": "WrittenCommunications", "nsuri": "http://xbrl.sec.gov/dei/2020-01-31", "presentation": [ "http://annovisbio.com/role/Cover" ], "xbrltype": "booleanItemType" } }, "unitCount": 3 } }, "std_ref": { "r0": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "12", "Subsection": "b" }, "r1": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "12", "Subsection": "b-23" }, "r10": { "Name": "Form 10-Q", "Number": "240", "Publisher": "SEC", "Section": "308", "Subsection": "a" }, "r11": { "Name": "Form 20-F", "Number": "249", "Publisher": "SEC", "Section": "220", "Subsection": "f" }, "r12": { "Name": "Form 40-F", "Number": "249", "Publisher": "SEC", "Section": "240", "Subsection": "f" }, "r13": { "Name": "Forms 10-K, 10-Q, 20-F", "Number": "240", "Publisher": "SEC", "Section": "13", "Subsection": "a-1" }, "r14": { "Name": "Regulation 12B", "Number": "240", "Publisher": "SEC", "Section": "12", "Subsection": "b-2" }, "r15": { "Name": "Regulation S-T", "Number": "232", "Publisher": "SEC", "Section": "405" }, "r16": { "Name": "Securities Act", "Number": "230", "Publisher": "SEC", "Section": "425" }, "r17": { "Name": "Securities Act", "Number": "7A", "Publisher": "SEC", "Section": "B", "Subsection": "2" }, "r18": { "Name": "Securities Act", "Number": "Section", "Publisher": "SEC", "Section": "12" }, "r2": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "12", "Subsection": "d1-1" }, "r3": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "12", "Subsection": "g" }, "r4": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "12, 13, 15d" }, "r5": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "13e", "Subsection": "4c" }, "r6": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "14d", "Subsection": "2b" }, "r7": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "15", "Subsection": "d" }, "r8": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "14a", "Subsection": "12" }, "r9": { "Name": "Form 10-K", "Number": "249", "Publisher": "SEC", "Section": "310" } }, "version": "2.1" } ZIP 15 0001104659-21-103213-xbrl.zip IDEA: XBRL DOCUMENT begin 644 0001104659-21-103213-xbrl.zip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end