0001104659-22-005057 5 1 20211231 20220118 20220118 Maccecchini Maria-Luisa 0001315018 5 34 001-39202 22536604 1223 FOXGLOVE LANE WEST CHESTER PA 19380 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 5 1 tm221949-8_5seq1.xml OWNERSHIP DOCUMENT FORM 5 OMB APPROVAL [ ] Check this OMB Number: box if no longer 3235-0362 subject to Estimated Section 16. Form average burden 4 or Form 5 UNITED STATES SECURITIES AND EXCHANGE COMMISSION hours per obligations may Washington, D.C. 20549 response... 1.0 continue. See ANNUAL STATEMENT OF CHANGES IN BENEFICIAL Instruction OWNERSHIP OF SECURITIES 1(b). [ ] Form 3 Holdings Reported [ ] Form 4 Transactions Reported Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940 1. Name and Address of Reporting 2. Issuer Name and Ticker 5. Relationship of Person * or Trading Symbol Reporting Person(s) to Maccecchini Maria-Luisa Annovis Bio, Inc. [ANVS] Issuer (Check all applicable) __X__ Director __X__ 10% Owner __X__ Officer (give title (Last) (First) (Middle) 3. Statement for Issuer's below) _____ Other C/O ANNOVIS BIO, INC., 1055 Fiscal Year Ended (specify below) WESTLAKES DRIVE, SUITE 300 (MM/DD/YYYY) President and CEO 12/31/2021 (Street) 4. If Amendment, Date 6. Individual or BERWYN, PA 19312 Original Filed(MM/DD/YYYY) Joint/Group Filing(Check (City) (State) (Zip) Applicable Line) _X_ Form Filed by One Reporting Person ___ Form Filed by More than One Reporting Person Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security 2. Trans. Date 2A. 3. Trans. Code 4. Securities Acquired (A) 5. Amount of 6. Ownership 7. Nature of (Instr. 3) Deemed (Instr. 8) or Disposed of (D) Securities Form: Direct (D) Indirect Execution (Instr. 3, 4 and 5) Beneficially or Indirect (I) Beneficial Date, if Owned Following (Instr. 4) Ownership any Reported (Instr. 4) Transaction(s) (A) (Instr. 3 and 4) or Amount (D) Price Common Stock 4/27/2020 G5 (1) 10000 (2) D $0 986775 D Common Stock 7/15/2020 G5 (1) 10000 (2) D $0 976775 D Common Stock 7/1/2021 G 1000 (2) D $0 975775 D Common Stock 7/1/2021 G 1000 (2) D $0 974775 D Common Stock 12/20/2021 G 20000 (2) D $0 954775 D Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities) 1. Title of 2. 3. 3A. 4. Trans. Code 5. Number of 6. Date Exercisable 7. Title and Amount of 8. Price 9. Number of 10. 11. Nature Derivate Conversion Trans. Deemed (Instr. 8) Derivative and Expiration Date Securities Underlying of Derivative Ownership of Security or Date Execution Securities (MM/DD/YYYY) Derivative Security Derivative Securities Form of Indirect (Instr. 3) Exercise Date, if Acquired (A) or (Instr. 3 and 4) Security Beneficially Derivative Beneficial Price of any Disposed of (D) (Instr. 5) Owned at End Security: Ownership Derivative (Instr. 3, 4 and of Issuer's Direct (D) (Instr. 4) Security 5) Fiscal Year or (Instr. 4) Indirect Date Expiration Amount or (I) Exercisable Date Title Number of (Instr. 4) (A) (D) Shares Explanation of Responses: (1) Charitable gift that was not previously reported in a Form 5 for the fiscal year ended December 31, 2020. (2) Charitable gift. Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Maccecchini Maria-Luisa C/O ANNOVIS BIO, INC. X X President and CEO 1055 WESTLAKES DRIVE, SUITE 300 BERWYN, PA 19312 Signatures /s/ Jeffrey McGroarty, Attorney-in-Fact for Maria L. Maccecchini 1/18/2022 ** Signature of Reporting Person Date Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. * If the form is filed by more than one reporting person, see Instruction 4(b)(v). ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure. Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.