0001104659-23-120304 4 1 20231120 20231121 20231121 Hoffman Michael B 0001290208 4 34 001-39202 231426802 (203) 413-2200 1 GREENWICH OFFICE PARK GREENWICH CT 06831 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm2331305-5_4seq1.xml OWNERSHIP DOCUMENT X0508 4 2023-11-20 0 0001477845 Annovis Bio, Inc. ANVS 0001290208 Hoffman Michael B C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 0 1 0 0 Common Stock 2023-11-20 4 A 0 164745 6.07 A 224222 I The 2018 Jane and Michael Hoffman Descendants Trust Common Stock 1416283 D The shares are held in a family trust formed by the reporting person and the reporting person has voting and investment power over such shares. /s/ Henrey Hagopian III, Attorney-in-Fact for Michael Hoffman 2023-11-21