0001104659-22-001643 4 1 20220103 20220105 20220105 McGroarty Jeffrey Brian 0001563273 4 34 001-39202 22513188 360 HILLTOP RD PAOLI PA 19301 McGroarty Jeffrey B 20121129 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm221949-5_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2022-01-03 0 0001477845 Annovis Bio, Inc. ANVS 0001563273 McGroarty Jeffrey Brian C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 0 1 0 0 Chief Financial Officer Stock Option (right to buy) 19.78 2022-01-03 4 A 0 28000 0 A 2032-01-03 Common Stock 28000 28000 D The stock option shall vest in eight consecutive quarterly installments of 3,500 shares each on the 3rd day of April, July, October and January of each year, commencing April 3, 2022, and continuing through January 3, 2024. /s/ Jeffrey McGroarty 2022-01-05