0001104659-23-120299 4 1 20231120 20231121 20231121 Bruck Claudine 0001733680 4 34 001-39202 231426752 4995 BRADENTON AVE, SUITE 240 DUBLIN OH 43017-3552 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm2331305-1_4seq1.xml OWNERSHIP DOCUMENT X0508 4 2023-11-20 0 0001477845 Annovis Bio, Inc. ANVS 0001733680 Bruck Claudine C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 0 0 0 0 Common Stock 2023-11-20 4 A 0 1000 6.07 A 7567 D /s/ Henrey Hagopian III, Attorney-in-Fact for Claudine Bruck 2023-11-21