0001104659-23-044202 4 1 20230407 20230411 20230411 Maccecchini Maria-Luisa 0001315018 4 34 001-39202 23814488 1223 FOXGLOVE LANE WEST CHESTER PA 19380 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm2312464-1_4seq1.xml OWNERSHIP DOCUMENT X0407 4 2023-04-07 0 0001477845 Annovis Bio, Inc. ANVS 0001315018 Maccecchini Maria-Luisa C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 1 1 0 President and CEO 0 Common Stock 2023-04-07 4 A 0 20000 12.61 A 1060489 D /s/ Henry Hagopian III, Attorney-in-Fact for Maria L. Maccecchini 2023-04-11