0001104659-23-044204 4 1 20230407 20230411 20230411 Hoffman Michael B 0001290208 4 34 001-39202 23814490 (203) 413-2200 1 GREENWICH OFFICE PARK GREENWICH CT 06831 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm2312464-3_4seq1.xml OWNERSHIP DOCUMENT X0407 4 2023-04-07 0 0001477845 Annovis Bio, Inc. ANVS 0001290208 Hoffman Michael B C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 0 1 0 0 Common Stock 2023-04-07 4 A 0 59477 12.61 A 59477 I The 2018 Jane and Michael Hoffman Descendants Trust Common Stock 1416283 D The shares are held in a family trust formed by the reporting person and the reporting person has voting and investment power over such shares. /s/ Henry Hagopian III, Attorney-in-Fact for Michael Hoffman 2023-04-11