0001104659-23-014610 4 1 20230206 20230208 20230208 Maccecchini Maria-Luisa 0001315018 4 34 001-39202 23600049 1223 FOXGLOVE LANE WEST CHESTER PA 19380 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm231947-2_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2023-02-06 0 0001477845 Annovis Bio, Inc. ANVS 0001315018 Maccecchini Maria-Luisa C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 1 1 0 President and CEO Common Stock 2023-02-06 4 M 0 52755 0.14 A 1040489 D Stock Option (right to buy) 0.14 2023-02-06 4 M 0 52755 0 D 2027-04-01 Common Stock 52755 0 D All of the shares underlying the option are fully vested and exercisable. /s/ Henry Hagopian, III, Attorney-in-Fact for Maria L. Maccecchini 2023-02-08