0001104659-23-044206 4 1 20230407 20230411 20230411 Hagopian Henry III 0001821822 4 34 001-39202 23814492 C/O ORGANOGENESIS INC., 85 DAN ROAD CANTON MA 02021 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm2312464-4_4seq.xml OWNERSHIP DOCUMENT X0407 4 2023-04-07 0 0001477845 Annovis Bio, Inc. ANVS 0001821822 Hagopian Henry III C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 0 1 0 0 Chief Financial Officer 0 Common Stock 2023-04-07 4 A 0 1000 12.61 A 1000 D /s/ Henry Hagopian III 2023-04-11