0001104659-23-120762 4/A 1 20231120 20231122 20231122 Maccecchini Maria-Luisa 0001315018 4/A 34 001-39202 231433795 1223 FOXGLOVE LANE WEST CHESTER PA 19380 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4/A 1 tm2331305-11_4aseq1.xml OWNERSHIP DOCUMENT X0508 4/A 2023-11-20 2023-11-21 0 0001477845 Annovis Bio, Inc. ANVS 0001315018 Maccecchini Maria-Luisa C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 1 1 0 President and CEO 0 Common Stock 2023-11-20 4 A 0 40970 6.10 A 1098459 D This amendment is being filed solely to reflect the modification of the terms of the previously reported purchase on the original form 4 filed on November 21, 2023 (the "Original Form 4"), as agreed to by the registrant and the reporting person on November 22, 2023. /s/ Henrey Hagopian III, Attorney-in-Fact for Maria L. Maccecchini 2023-11-22