0001104659-23-120760 4/A 1 20231120 20231122 20231122 Hagopian Henry III 0001821822 4/A 34 001-39202 231433768 C/O ORGANOGENESIS INC., 85 DAN ROAD CANTON MA 02021 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4/A 1 tm2331305d8_4a.xml OWNERSHIP DOCUMENT X0508 4/A 2023-11-20 2023-11-21 0 0001477845 Annovis Bio, Inc. ANVS 0001821822 Hagopian Henry III C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 0 1 0 0 Chief Financial Officer 0 Common Stock 2023-11-20 4 A 0 820 6.10 A 1820 D This amendment is being filed solely to reflect the modification of the terms of the previously reported purchase on the original form 4 filed on November 21, 2023 (the "Original Form 4"), as agreed to by the registrant and the reporting person on November 22, 2023. /s/ Henrey Hagopian III 2023-11-22