0001104659-22-005057 5 1 20211231 20220118 20220118 Maccecchini Maria-Luisa 0001315018 5 34 001-39202 22536604 1223 FOXGLOVE LANE WEST CHESTER PA 19380 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 5 1 tm221949-8_5seq1.xml OWNERSHIP DOCUMENT X0306 5 2021-12-31 0 0 0 0001477845 Annovis Bio, Inc. ANVS 0001315018 Maccecchini Maria-Luisa C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 1 1 0 President and CEO Common Stock 2020-04-27 5 G 0 L 10000 0 D 986775 D Common Stock 2020-07-15 5 G 0 L 10000 0 D 976775 D Common Stock 2021-07-01 5 G 0 1000 0 D 975775 D Common Stock 2021-07-01 5 G 0 1000 0 D 974775 D Common Stock 2021-12-20 5 G 0 20000 0 D 954775 D Charitable gift that was not previously reported in a Form 5 for the fiscal year ended December 31, 2020. Charitable gift. /s/ Jeffrey McGroarty, Attorney-in-Fact for Maria L. Maccecchini 2022-01-18