0001104659-21-147676 4 1 20211206 20211208 20211208 McGroarty Jeffrey Brian 0001563273 4 34 001-39202 211479379 360 HILLTOP RD PAOLI PA 19301 McGroarty Jeffrey B 20121129 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4 1 tm2134914d2_4seq1.xml OWNERSHIP DOCUMENT X0306 4 2021-12-06 0 0001477845 Annovis Bio, Inc. ANVS 0001563273 McGroarty Jeffrey Brian C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 0 1 0 0 Chief Financial Officer Stock Option (right to buy) 20.97 2021-12-06 4 A 0 30396 0 A 2021-12-06 2031-12-06 Common Stock 30396 30396 D Stock Option (right to buy) 20.97 2021-12-06 4 A 0 165199 0 A 2031-12-06 Common Stock 165199 165199 D The stock option is 100% vested. The stock option shall vest in two installments: (i) the first installment of 82,600 shares on March 31, 2022 and (ii) a second and final installment of 82,599 shares on March 31, 2023, provided that the reporting person continues to be employed by the issuer on the applicable vesting date. /s/ Jeffrey McGroarty 2021-12-08