0001104659-23-120764 4/A 1 20231120 20231122 20231122 Hoffman Michael B 0001290208 4/A 34 001-39202 231433807 (203) 413-2200 1 GREENWICH OFFICE PARK GREENWICH CT 06831 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 4/A 1 tm2331305-9_4aseq1.xml OWNERSHIP DOCUMENT X0508 4/A 2023-11-20 2023-11-21 0 0001477845 Annovis Bio, Inc. ANVS 0001290208 Hoffman Michael B C/O ANNOVIS BIO, INC. 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 1 0 1 0 0 Common Stock 2023-11-20 4 A 0 163880 6.10 A 223357 I The 2018 Jane and Michael Hoffman Descendants Trust Common Stock 1416283 D The shares are held in a family trust formed by the reporting person and the reporting person has voting and investment power over such shares. This amendment is being filed solely to reflect the modification of the terms of the previously reported purchase on the original form 4 filed on November 21, 2023 (the "Original Form 4"), as agreed to by the registrant and the reporting person on November 22, 2023. /s/ Henrey Hagopian III, Attorney-in-Fact for Michael Hoffman 2023-11-22