9999999995-21-000612 EFFECT 1 20210211 20210212 20210211 Annovis Bio, Inc. 0001477845 2834 262540421 DE 1231 EFFECT 33 333-252625 21622452 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 610-727-3913 1055 WESTLAKES DRIVE, SUITE 300 BERWYN PA 19312 QR Pharma, Inc. 20091202 EFFECT 1 primary_doc.xml UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 NOTICE OF EFFECTIVENESS Effective Date: February 11, 2021 4:30 P.M. Form: S-3 CIK: 0001477845 Company Name: Annovis Bio, Inc. File Number: 333-252625