The clinical trial taking place at six sites, including the
The clinical trial was designed to test the effects of ANVS401, the Company’s lead compound, on neurotoxic proteins in human spinal fluid by stable isotope labeling kinetics (SILK) for the treatment of Alzheimer’s disease.
This study is breaking new ground in the Alzheimer’s field. It combines state-of-the-art SILK to evaluate the effects of ANVS401 on neurotoxic proteins in spinal fluid with safety, pharmacokinetics, pharmacodynamics and efficacy.
Maria Maccecchini, Ph.D., CEO of Annovis, commented, “We are extremely pleased that the Data Safety Monitoring Board has unanimously supported that the study continues without modification. This trial will provide proof of mechanism and proof of concept for ANVS401. It will also provide the necessary dose range and safety information we need to progress our drug development into pivotal phase II/III clinical efficacy studies.
"We believe our approach to the treatment of Alzheimer’s is unique. There have been over 500 failed attempts at developing Alzheimer’s drugs. But we have taken a different approach by focusing on improving the information highway of the nerve cell. Our lead compound, ANVS401, is the only drug to improve axonal transport, the information highway of the nerve cell, by attacking multiple neurotoxic proteins simultaneously. We look forward to receiving interim results in the fourth quarter of this year.”
About ADCS: ADCS was formed in 1991 as a cooperative agreement between the
This press release contains “forward-looking statements” about the company’s current expectations about future results, performance, prospects and opportunities. Statements that are not historical facts, such as “anticipates,” “believes” and “expects” or similar expressions, are forward-looking statements. These statements are subject to a number of risks, uncertainties and other factors that could cause actual results in future periods to differ materially from what is expressed in, or implied by, these statements. The factors which may influence the company’s future performance include the company’s ability to obtain additional capital to expand operations as planned, success in achieving regulatory approval for clinical protocols, enrollment of adequate numbers of patients in clinical trials, unforeseen difficulties in showing efficacy of the company’s biopharmaceutical products, success in attracting additional customers and profitable contracts, and regulatory risks associated with producing pharmaceutical grade and food products. These and other risk factors are described from time to time in the company’s filings with the
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